Alzheimer's Disease

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Alzheimer's disease (AD), also known simply as Alzheimer's, is a neurodegenerative disease that, in its most common form, is found in people over age 65. Approximately 24 million people worldwide have dementia of which the majority (~60%) is due to Alzheimer's.

Clinical signs of Alzheimer's disease are characterized by progressive cognitive deterioration, together with declining activities of daily living and by neuropsychiatric symptoms or behavioural changes. It is the most common type of dementia. Plaques which contain misfolded peptides called amyloid beta (Aâ) are formed in the brain many years before the clinical signs of Alzheimer's are observed. This serious disease is plaguing the Western World in such a way that just about every individual has had an experience with someone with Alzheimer’s in one way or another. Alzheimer’s is a devastating disease that affects the mind, and more specifically your memory. 1 in 8 individuals over the age of 65 will develop it.

Risk Factors:

We currently don’t know what exactly causes Alzheimer’s, and it remains a disease that is diagnosed by eliminating other possibilities. However, experts have found a number of factors that reoccur in Alzheimer’s patients. It is believed that a combination of the following factors can cause a person to be predisposed to develop Alzheimer’s.

1. Family history of the disease – especially a parent or sibling.
2. Heart-disease risk factors such as high blood pressure, smoking, obesity, and diabetes.
3. Previous head injury
4. Environmental toxins
5. Advancing age
6. Stress- high levels of anxiety

What Are the Symptoms of AD?

AD begins slowly. At first, the only symptom may be mild forgetfulness, which can be confused with age-related memory change. Most people with mild forgetfulness do not have AD. In the early stage of AD, people may have trouble remembering recent events, activities, or the names of familiar people or things. They may not be able to solve simple math problems. Such difficulties may be a bother, but usually they are not serious enough to cause alarm.

However, as the disease goes on, symptoms are more easily noticed and become serious enough to cause people with AD or their family members to seek medical help. Forgetfulness begins to interfere with daily activities.

Main Stages of Alzheimer’s Disease:

Experts have identified a number of stages to help define and group people suffering from this devastating and difficult disease. With no cure the best thing you can do is be aware of what this disease may bring in the future and use this knowledge to help plan care for your loved one.

The following are the Three Main Stages:

1. Early-State – In the early stage, the individual will suffer memory loss and possibly some other cognitive difficulties, however, they can continue to function independently.

2. Mid-Stage – In the mid-stage, the disease has progressed past basic memory troubles and the individual’s mental abilities have continued to decline. They start to suffer personality changes and physical problems, and in turn become more dependent on caregivers.

3. Late-Stage – The late-stage is the most severe. Individuals will suffer complete deterioration of the personality and loss of control over bodily functions. They will become totally dependent on caregivers for even basic daily needs.

There is no set time as to when a person will progress from one stage to the other. One individual may move quickly from the early-stage to the mid-stage, while another may stay in the early-stage for several years. Every person is different. Here is a basic break down of the types of symptoms and their severity for each stage:

How is the diagnosis of Alzheimer's disease made?

As of June 2007, there is no specific "blood test" or imaging test that is used for the diagnosis of Alzheimer's disease. Alzheimer's disease is diagnosed when: 1) a person has sufficient cognitive decline to meet criteria for dementia; 2) the clinical course is consistent with that of Alzheimer's disease; 3) no other brain diseases or other processes are better explanations for the dementia.

Treatment

Currently, there's no cure for Alzheimer's disease. Doctors sometimes prescribe drugs to improve symptoms that often accompany Alzheimer's, including sleeplessness, wandering, anxiety, agitation and depression. But only two varieties of medications have been proved to slow the cognitive decline associated with Alzheimer's.

What can I do to help myself?

The first thing is not to worry unnecessarily. A problem with forgetfulness doesn't mean that you have dementia.

If you find yourself forgetting certain things, you could try to give yourself memory prompts. If (for instance) you find that you forget to buy food, leave notes in your kitchen cupboards near the back, reminding you to go to the shops. So when you come across the notes, keep them on you until you have bought more food.

This may seem cumbersome, but it's only an extension of the 'to do' lists that people make in everyday life.

Published 21st Feb 2007

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